AICAR
Metabolic Health · AMPK activator / exercise mimetic
Tier D
What this is
WADA coverage: AICAR and the broader AMPK-activator exercise-mimetic class. Strong interest comes from the exercise-in-a-pill story, not from proven human longevity benefit. Additional WADA alias coverage: Peroxisome proliferator-activated receptor delta (PPARdelta) agonists and the GW1516/GW501516 chemical entry are covered here as the broader exercise-mimetic class and by the dedicated Cardarine row.
Mechanism
AICAR activates AMPK-linked signaling and became famous as an “exercise mimetic” after preclinical endurance studies; human enhancement evidence is thin.
Dose & route
No approved performance dose
Citations
- https://pubmed.ncbi.nlm.nih.gov/29765854/
- https://pubmed.ncbi.nlm.nih.gov/25179079/
- https://www.wada-ama.org/en/resources/2026-prohibited-list
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.