Dietary nucleotide supplementation
Cognitive · Nucleotide blend / nutritional geroprotector
Tier B+
What this is
One of the more interesting 'new nutrition' entries, but it is still one trial, not a settled category. A 2025 triple-blind RCT in 69 independent adults aged 60-75 reported improvements versus placebo in physical performance, Trail Making Test B, oxidative-stress biomarkers, inflammatory cytokines, quality of life, and body-composition maintenance while participants continued spontaneous activity. Treat as promising, especially for aging/cognition/muscle overlap; do not overread it as proven lifespan biology.
Mechanism
Dietary nucleotides support purine/pyrimidine pools for DNA/RNA synthesis, repair, immune and gut-cell turnover, and may influence neurogenesis, redox balance, inflammation, and muscle adaptation in older adults.
Dose & route
Product-specific; no standardized dose. 2025 RCT compared a yeast nucleotide formulation (>40% free nucleotides) and a 5'-monophosphate nucleotide blend for 10 weeks.
Citations
- https://pubmed.ncbi.nlm.nih.gov/40362739/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12073346/
- https://doi.org/10.3390/nu17091431
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.