Ipamorelin
Muscle & Strength · Selective ghrelin receptor agonist
Tier C
What this is
The 'cleanest' of the GHRPs — minimal effect on cortisol and prolactin. Classic stack: CJC-1295 (no DAC) + Ipamorelin to produce a synchronized GH pulse. Ph2 studies for postoperative ileus in Helsinn development program; no approval. Product-quality caveat: a 2026 preprint testing consumer "research-grade" peptides found 42-71% failed purity benchmarks and ~15% had measurable endotoxin contamination — gray-market sourcing is a real safety risk.
Mechanism
Selective GHS-R1a agonist; releases GH from pituitary with minimal impact on cortisol, prolactin, ACTH (unlike GHRP-2/6); short plasma half-life (~2 hr)
Dose & route
200-300 mcg subQ 2-3x/day (commonly stacked with CJC-1295)
Citations
- https://pubmed.ncbi.nlm.nih.gov/9747020/
- https://pubmed.ncbi.nlm.nih.gov/18443304/
- https://pubmed.ncbi.nlm.nih.gov/24170034/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.