Meldonium
Metabolic Health · Carnitine-pathway metabolic modulator
Tier C-
What this is
Added from WADA S4.4.3. The Sharapova case made meldonium famous, but the human performance evidence remains much less decisive than the doping notoriety.
Mechanism
Meldonium shifts cardiac and skeletal-muscle energy metabolism by inhibiting carnitine synthesis/transport; athletes have used it for perceived endurance and recovery benefits.
Dose & route
Clinical dosing varies by country/indication; no approved performance dose
Citations
- https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2026.1822778/full
- https://www.wada-ama.org/en/resources/2026-prohibited-list
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.