Noopept (GVS-111)
Cognitive · Peptide-like
Tier C+
What this is
Developed at Zakusov Institute. ~1000x more potent than piracetam by weight. Common in nootropic stacks. Sublingual absorption well-reported. Anxiolytic effect distinguishes from other racetam-likes.
Mechanism
Proline-containing dipeptide structurally similar to piracetam; increases BDNF and NGF; cycloprolylglycine metabolite with anxiolytic activity
Dose & route
10-30 mg PO or sublingual daily
Citations
- https://pubmed.ncbi.nlm.nih.gov/11915081/
- https://pubmed.ncbi.nlm.nih.gov/19240132/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6121265/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.