Ryanodine stabilizers / fast skeletal muscle troponin activators
Muscle & Strength · Muscle contractility modulator
Tier D
What this is
WADA coverage: ryanodine receptor-1-calstabin complex stabilizers, S-107, S48168/ARM210, troponin activators, reldesemtiv and tirasemtiv. Included as perceived muscle-performance enhancers, not established healthspan tools.
Mechanism
These agents target calcium leak or fast skeletal muscle troponin activation to improve contractile function or fatigue resistance, mostly in neuromuscular-disease development programs.
Dose & route
No approved performance dose
Citations
- https://clinicaltrials.gov/search?term=reldesemtiv
- https://www.wada-ama.org/en/resources/2026-prohibited-list
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