Trimetazidine
Metabolic Health · Cardiac metabolic modulator
Tier D+
What this is
Added from WADA S4.4.4. This is best understood as a cardiac metabolic drug that became a doping concern, not a general metabolic-health intervention.
Mechanism
Trimetazidine shifts myocardial substrate use toward glucose oxidation; sport use is framed as endurance/ischemia-resilience enhancement, but healthy-performance evidence is weak.
Dose & route
Clinical dosing varies by country/formulation; no performance dose
Citations
- https://www.ncbi.nlm.nih.gov/books/NBK305894/
- https://www.wada-ama.org/en/resources/2026-prohibited-list
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