Rankings / Immune & Inflammation

Immune & Inflammation

Vitamins, minerals, adaptogens, microbiome agents, and anti-inflammatory compounds. The microbiome-immune axis sits alongside more classical immune support.

Compounds ranked
18
Top-ranked
# Compound Class Ev Bn Sf Grade · Score
1 Rifaximin (Xifaxan)
Gut-selective antibiotic
Prescription 8.0 8.0 9.0 A+ 8.4
2 Probiotics (multi-strain)
Live microbial supplement
Supplement 8.0 5.0 9.0 A 8.0
3 Saccharomyces boulardii
Probiotic yeast
Supplement 8.0 5.0 9.0 A 8.0
4 Vitamin C (ascorbic acid)
Essential vitamin / antioxidant
Supplement 8.0 5.0 9.0 A 8.0
5 FMT (fecal microbiota transplantation)
Microbiome transplant
Prescription 10.0 8.0 5.0 A- 7.7
6 Butyrate (tributyrin / sodium butyrate)
Short-chain fatty acid
Supplement 6.0 5.0 9.0 B+ 7.1
7 Lactoferrin (bovine)
Iron-binding glycoprotein
Supplement 6.0 5.0 9.0 B+ 7.1
8 2'-fucosyllactose (2'-FL human milk oligosaccharide)
Human milk oligosaccharide / prebiotic
Supplement 6.0 3.5 9.0 B 6.8
9 Akkermansia muciniphila (pasteurized)
Next-generation probiotic
Supplement 6.0 3.5 9.0 B 6.8
10 Prebiotics (inulin / FOS / GOS / partially hydrolyzed guar gum)
Fermentable fibers
Supplement 6.0 5.0 7.0 B- 6.3
11 Beta-glucans (yeast / mushroom)
Polysaccharide PAMP mimetic
Supplement 4.5 3.5 9.0 B- 6.2
12 Colostrum (bovine)
Immunoglobulin-rich milk
Supplement 4.5 3.5 9.0 B- 6.2
13 Echinacea
Herbal immune modulator
Herbal 4.5 3.5 9.0 B- 6.2
14 Astragalus
Adaptogen / TA-65 source
Herbal 3.0 3.5 9.0 C+ 5.5
15 Elderberry (Sambucus nigra)
Anthocyanin-rich extract
Herbal 3.0 3.5 9.0 C+ 5.5
16 Quercetin
Flavonoid
Supplement 3.0 3.5 9.0 C+ 5.5
17 Systemic glucocorticoids (prednisone / dexamethasone / triamcinolone)
Glucocorticoid / anti-inflammatory steroid
Prescription 6.0 5.0 2.0 C- 4.3
18 Larazotide acetate (AT-1001)
Tight junction regulator
Supplement 3.0 3.0 4.0 D+ 3.4

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