Rankings / Mood, Anxiety & Stress
Mood, Anxiety & Stress
Antidepressants, anxiolytics, mood stabilisers, psychedelic medicines, and adaptogenic compounds for affective regulation. Prescription and natural agents combined.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | TMS (transcranial magnetic stimulation) Non-invasive neuromodulation | 8.0 | 8.0 | 9.0 | A+ 8.4 |
| 2 | Meditation / mindfulness Other | 8.0 | 6.5 | 9.0 | A+ 8.2 |
| 3 | Propranolol Non-selective beta-blocker | 8.0 | 3.5 | 9.0 | A- 7.7 |
| 4 | Buspirone 5-HT1A partial agonist | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 5 | Inositol (myo-inositol / D-chiro-inositol) Sugar alcohol / second messenger | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 6 | Saffron extract (Crocus sativus) Herbal (crocin/safranal) | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 7 | Bupropion (Wellbutrin) NDRI | 8.0 | 8.0 | 5.0 | B 6.8 |
| 8 | Dextromethorphan-bupropion (Auvelity / AXS-05) NMDA antagonist + sigma-1 agonist + NDRI | 8.0 | 8.0 | 5.0 | B 6.8 |
| 9 | Electroconvulsive therapy (ECT) Procedural neuromodulation (induced seizure) | 8.0 | 8.0 | 5.0 | B 6.8 |
| 10 | SNRIs (venlafaxine / duloxetine) Dual SERT/NET reuptake inhibitor | 8.0 | 8.0 | 5.0 | B 6.8 |
| 11 | Xanomeline-trospium (KarXT / Cobenfy) M1/M4 muscarinic agonist + peripheral antagonist | 8.0 | 8.0 | 5.0 | B 6.8 |
| 12 | Zuranolone (Zurzuvae) GABA-A neurosteroid (positive allosteric modulator) | 8.0 | 8.0 | 5.0 | B 6.8 |
| 13 | Breathwork (structured breathing) Autonomic | 6.0 | 3.5 | 9.0 | B 6.8 |
| 14 | Psilocybin Classic psychedelic / 5-HT2A agonist | 8.0 | 6.5 | 5.0 | B 6.6 |
| 15 | SSRIs (sertraline / escitalopram / fluoxetine) Selective serotonin reuptake inhibitor | 8.0 | 6.5 | 5.0 | B 6.6 |
| 16 | Gabapentin / pregabalin alpha-2-delta voltage-gated Ca channel modulator | 8.0 | 5.0 | 5.0 | B 6.4 |
| 17 | St. John's wort (Hypericum perforatum) Natural SSRI-SNRI-like | 8.0 | 5.0 | 5.0 | B 6.4 |
| 18 | Ashwagandha (Withania somnifera) Adaptogen | 6.0 | 5.0 | 7.0 | B- 6.3 |
| 19 | SAM-e (S-adenosylmethionine) Methyl donor | 6.0 | 5.0 | 7.0 | B- 6.3 |
| 20 | Lithium (microdose vs therapeutic) Mood stabilizer / geroprotector | 10.0 | 5.0 | 2.0 | B- 6.1 |
| 21 | Ketamine NMDA antagonist | 8.0 | 6.5 | 3.5 | B- 6.0 |
| 22 | LSD (lysergic acid diethylamide) Classic psychedelic / 5-HT2A agonist | 6.0 | 6.5 | 5.0 | C+ 5.7 |
| 23 | Kava (Piper methysticum) GABA-A modulator / TRPV1 | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 24 | Other beta-blockers (atenolol / metoprolol / nadolol) Beta-blocker / performance-anxiety agent | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 25 | Selegiline (L-deprenyl) MAO-B inhibitor | 6.0 | 3.5 | 5.0 | C+ 5.2 |
| 26 | MDMA (3,4-methylenedioxymethamphetamine) Entactogen | 6.0 | 6.5 | 3.5 | C 5.1 |
| 27 | Ayahuasca / DMT Classic psychedelic / 5-HT2A + MAOI combo | 4.5 | 6.5 | 3.5 | C- 4.4 |
| 28 | Tianeptine Atypical antidepressant / mu-opioid agonist | 6.0 | 5.0 | 2.0 | C- 4.3 |
| 29 | Ibogaine Iboga alkaloid / NMDA antagonist + kappa-opioid | 4.5 | 8.0 | 2.0 | C- 4.0 |
| 30 | 5-HTP (5-hydroxytryptophan) Serotonin precursor | 3.0 | 3.5 | 5.0 | D+ 3.9 |
| 31 | Phenibut (β-phenyl-GABA) GABA-B agonist (with weak GABA-A activity) | 3.0 | 5.0 | 2.0 | D 2.9 |