Glycine + NAC (GlyNAC)

What this is

Kumar/Sekhar Baylor team showed 16-week GlyNAC supplementation in older adults improved oxidative stress, mitochondrial function, insulin resistance, grip strength, gait speed, inflammatory markers, and multiple hallmarks of aging (Kumar 2023, J Gerontol). 2024 Sekhar follow-up (Innovation in Aging supplement, 24-week pilot) extended findings to age-associated cognitive decline with improved cognition plus metabolic and inflammatory markers. Critical caveat: benefits disappear ~12 weeks after stopping — continuous supplementation required to sustain effects. Preclinical Kumar 2023 (Antioxidants) describes a 'brain glucose steal' phenomenon — aged mitochondrial dysfunction shunts glucose away from the brain — that GlyNAC reversed in aged mice. MCI/Alzheimer pilots underway at Baylor.

Mechanism

Combined glycine + NAC replenishes glutathione (primary intracellular antioxidant); improves mitochondrial function; reduces oxidative stress and genotoxicity; shown to reverse multiple hallmarks of aging in older adults

Dose & route

Glycine 100 mg/kg + NAC 100 mg/kg daily (Kumar/Sekhar protocol)

Citations

• https://pubmed.ncbi.nlm.nih.gov/33876242/
• https://pubmed.ncbi.nlm.nih.gov/34746943/
• https://academic.oup.com/biomedgerontology/article/78/1/75/6624702
• https://www.mdpi.com/2076-3921/12/5/1042
• https://academic.oup.com/innovateage/article/8/Supplement_1/250/7936620

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