PEA (palmitoylethanolamide)
Sleep & Recovery · Endogenous fatty acid amide
Tier B+
What this is
Italian research tradition. Ultramicronized (um-PEA) form has better absorption than standard. Gabapentinoid-sparing in some chronic pain regimens. Synergistic with luteolin in some formulations.
Mechanism
Endocannabinoid-like fatty acid amide; PPAR-α agonist; 'entourage' amplification of endogenous anandamide; anti-inflammatory and analgesic via mast cell modulation
Dose & route
300-1200 mg/day PO (ultramicronized preferred for bioavailability)
Citations
- https://pubmed.ncbi.nlm.nih.gov/28347101/
- https://pubmed.ncbi.nlm.nih.gov/31484509/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6281805/
- https://pubmed.ncbi.nlm.nih.gov/41709243/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.