Rankings / Sleep & Recovery
Sleep & Recovery
Sleep aids and exercise/tissue-recovery compounds — melatonin, GABAergic agents, peptides, antioxidants, collagen, omega-3 in the recovery framing.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Suzetrigine (Journavx / VX-548) Selective Nav1.8 sodium channel inhibitor | 8.0 | 6.5 | 9.0 | A+ 8.2 |
| 2 | Melatonin Pineal hormone | 8.0 | 3.5 | 9.0 | A- 7.7 |
| 3 | Cognitive behavioral therapy for insomnia (CBT-I) Behavioral sleep | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 4 | DORAs (suvorexant / lemborexant / daridorexant) Orexin receptor antagonists | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 5 | Sunlight / circadian light exposure Light | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 6 | HMB (β-hydroxy β-methylbutyrate) Leucine metabolite | 6.0 | 3.5 | 10.0 | B+ 7.2 |
| 7 | Boswellia serrata (AKBA) Boswellic acid / 5-LOX inhibitor | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 8 | Circadian-aligned eating Fasting | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 9 | Doxepin (low-dose) H1 antagonist (low dose) | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 10 | HRV-guided training / biofeedback Other | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 11 | PEA (palmitoylethanolamide) Endogenous fatty acid amide | 6.0 | 5.0 | 9.0 | B+ 7.1 |
| 12 | Tart cherry (Prunus cerasus) Anthocyanin-rich fruit extract | 6.0 | 2.0 | 10.0 | B+ 7.0 |
| 13 | Hyaluronic acid (oral + intra-articular) Glycosaminoglycan | 6.0 | 3.5 | 9.0 | B 6.8 |
| 14 | Mobility work / flexibility training Movement | 6.0 | 3.5 | 9.0 | B 6.8 |
| 15 | PEMF therapy (pulsed electromagnetic field) Other | 6.0 | 3.5 | 9.0 | B 6.8 |
| 16 | Glutamine Amino acid | 6.0 | 2.0 | 9.0 | B 6.6 |
| 17 | Contrast therapy (hot/cold) Thermal | 6.0 | 5.0 | 7.0 | B- 6.3 |
| 18 | Trazodone 5-HT2A antagonist / SARI | 6.0 | 5.0 | 7.0 | B- 6.3 |
| 19 | Glucosamine + chondroitin Joint matrix substrate | 4.0 | 3.5 | 10.0 | B- 6.3 |
| 20 | Z-drugs (zolpidem / eszopiclone / zaleplon) GABA-A alpha-1 positive modulators | 8.0 | 8.0 | 3.5 | B- 6.2 |
| 21 | Glycine Amino acid / NMDA co-agonist | 4.5 | 3.5 | 9.0 | B- 6.2 |
| 22 | Valerian (Valeriana officinalis) Herbal sedative | 4.5 | 3.5 | 9.0 | B- 6.2 |
| 23 | Thymosin alpha-1 Immunomodulatory peptide | 3.0 | 5.0 | 9.0 | C+ 5.7 |
| 24 | Cold plunge / cold water immersion Thermal | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 25 | Curcumin (turmeric) Polyphenol | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 26 | Hyperbaric oxygen therapy (HBOT) Oxygen/Pressure | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 27 | Apigenin Flavonoid / GABA-A modulator | 3.0 | 3.5 | 9.0 | C+ 5.5 |
| 28 | CBD (cannabidiol) Non-psychoactive cannabinoid | 4.5 | 3.5 | 7.0 | C+ 5.4 |
| 29 | SPMs (specialized pro-resolving mediators) Lipid signaling molecules | 2.0 | 3.5 | 9.0 | C 5.0 |
| 30 | Pentosan polysulfate (Elmiron) Semisynthetic heparinoid | 4.5 | 5.0 | 5.0 | C 4.8 |
| 31 | THC / cannabis products Cannabinoid / THC agonist | 3.5 | 3.5 | 5.0 | C- 4.1 |
| 32 | High-volume IV hydration / infusion clinics IV infusion protocol | 3.0 | 3.5 | 5.0 | D+ 3.9 |
| 33 | KPV (Lys-Pro-Val) Tripeptide (alpha-MSH fragment) | 2.0 | 5.0 | 4.0 | D 3.3 |
| 34 | LL-37 (cathelicidin) Antimicrobial peptide | 2.0 | 5.0 | 4.0 | D 3.3 |
| 35 | Tramadol / prescription opioid analgesics Opioid analgesic / pain masking | 3.0 | 5.0 | 2.0 | D 2.9 |
| 36 | BPC-157 (Body Protection Compound-157) Pentadecapeptide | 2.0 | 5.0 | 3.0 | D 2.9 |
| 37 | TB-500 (Thymosin beta-4 fragment) Synthetic peptide | 2.0 | 5.0 | 3.0 | D 2.9 |