Rankings / Hormones & Endocrine
Yohimbine
Hormones & Endocrine · Alpha-2 adrenergic antagonist
Tier C
What this is
Yohimbine HCl and yohimbe bark are distinct — the latter has unpredictable alkaloid content including rauwolscine. Strong adrenergic effects make it dangerous in anxiety-prone individuals. Pairs badly with caffeine or stimulants.
Mechanism
Alkaloid from Pausinystalia johimbe bark; selective α2-adrenergic antagonist; increases peripheral and central noradrenergic tone; historical use for ED before PDE5i era
Dose & route
5-10 mg yohimbine HCl 2-3x/day (fat loss); 10-20 mg PRN (ED)
Citations
- https://pubmed.ncbi.nlm.nih.gov/9609743/
- https://pubmed.ncbi.nlm.nih.gov/16247815/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6323031/
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