Rankings / Hormones & Endocrine
Hormones & Endocrine
HRT, thyroid, sex-hormone modulators, libido pharmacotherapy, and androgen-pathway agents for hair. Powerful when indicated; outcomes depend on who is taking them and why.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Tadalafil (Cialis) Long-acting PDE5 inhibitor | 10.0 | 10.0 | 7.0 | S 8.8 |
| 2 | Minoxidil (topical + oral low-dose) Potassium channel opener / vasodilator | 8.0 | 8.0 | 9.0 | A+ 8.4 |
| 3 | Sildenafil (Viagra) PDE5 inhibitor | 10.0 | 10.0 | 5.0 | A 8.0 |
| 4 | Progesterone (micronized / oral / vaginal) Progesterone replacement | 8.0 | 5.0 | 9.0 | A 8.0 |
| 5 | Elinzanetant (Lynkuet) NK1/NK3 dual receptor antagonist (non-hormonal) | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 6 | Finasteride (oral / topical) 5-alpha reductase inhibitor (type II) | 8.0 | 8.0 | 7.0 | A- 7.6 |
| 7 | Gonadorelin (GnRH) Pulsatile GnRH analog | 8.0 | 5.0 | 7.0 | B+ 7.2 |
| 8 | HCG (human chorionic gonadotropin) LH-analog gonadotropin | 8.0 | 5.0 | 7.0 | B+ 7.2 |
| 9 | Cabergoline Dopamine D2 agonist | 8.0 | 8.0 | 5.0 | B 6.8 |
| 10 | Dutasteride 5-alpha reductase inhibitor (type I+II) | 8.0 | 8.0 | 5.0 | B 6.8 |
| 11 | Estradiol (HRT — oral/transdermal/vaginal) Estrogen replacement | 8.0 | 8.0 | 5.0 | B 6.8 |
| 12 | Fezolinetant (Veozah) NK3 receptor antagonist (non-hormonal) | 8.0 | 8.0 | 5.0 | B 6.8 |
| 13 | Resmetirom (Rezdiffra) Liver-selective THR-β agonist | 8.0 | 8.0 | 5.0 | B 6.8 |
| 14 | Spironolactone Aldosterone / androgen receptor antagonist | 8.0 | 8.0 | 5.0 | B 6.8 |
| 15 | Maca (Lepidium meyenii) Andean cruciferous tuber | 6.0 | 3.5 | 9.0 | B 6.8 |
| 16 | Tongkat ali (Eurycoma longifolia) Adaptogen / T-optimizer | 6.0 | 3.5 | 9.0 | B 6.8 |
| 17 | Romosozumab (Evenity) Sclerostin antibody (bone anabolic) | 8.0 | 10.0 | 3.5 | B 6.5 |
| 18 | Anastrozole Aromatase inhibitor | 8.0 | 5.0 | 5.0 | B 6.4 |
| 19 | T4 / NDT (levothyroxine, desiccated thyroid) Thyroid hormone replacement | 8.0 | 5.0 | 5.0 | B 6.4 |
| 20 | Enclomiphene citrate SERM (HPG restart) | 6.0 | 5.0 | 7.0 | B- 6.3 |
| 21 | T3 (liothyronine) Active thyroid hormone | 8.0 | 8.0 | 3.5 | B- 6.2 |
| 22 | Kisspeptin-10 Hypothalamic peptide | 4.5 | 3.5 | 9.0 | B- 6.2 |
| 23 | DHEA Adrenal steroid precursor | 6.0 | 3.5 | 7.0 | B- 6.0 |
| 24 | Clomiphene citrate SERM (HPG restart) | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 25 | Other aromatase inhibitors (letrozole / exemestane / formestane / arimistane) Aromatase inhibitor | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 26 | Other SERMs / anti-estrogens (tamoxifen / raloxifene / fulvestrant) SERM / estrogen receptor modulator | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 27 | PT-141 (Bremelanotide / Vyleesi) Melanocortin receptor agonist | 6.0 | 5.0 | 5.0 | C+ 5.5 |
| 28 | Pregnenolone Neurosteroid / upstream precursor | 3.0 | 3.5 | 9.0 | C+ 5.5 |
| 29 | Tribulus terrestris Saponin-containing herb | 3.0 | 3.5 | 9.0 | C+ 5.5 |
| 30 | GnRH/LH-axis analogs for testosterone stimulation HPG-axis peptide / gonadotropin manipulation | 6.0 | 5.0 | 3.5 | C 4.9 |
| 31 | Yohimbine Alpha-2 adrenergic antagonist | 6.0 | 5.0 | 3.5 | C 4.9 |
| 32 | Melanotan II (MT-II) Non-selective melanocortin agonist | 6.0 | 6.5 | 2.0 | C- 4.5 |
| 33 | ACTH / corticotrophin analogs Corticotrophin / adrenal-axis stimulant | 3.0 | 3.5 | 3.5 | D 3.3 |
| 34 | Osilodrostat Cortisol synthesis inhibitor | 3.0 | 2.0 | 2.0 | D- 2.5 |
| 35 | Fadogia agrestis Nigerian shrub | 0.0 | 5.0 | 3.0 | F 2.0 |